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Consult the labeling of all concurrently used drugs to obtain further information about interactions with COUMADIN or adverse reactions pertaining to bleeding.

Hemorrhagesee BOX WARNINGWARNINGS AND PRECAUTIONS and OVERDOSETissue Necrosissee WARNINGS AND PRECAUTIONSCalciphylaxissee WARNINGS AND PRECAUTIONSAcute Kidney Injurysee WARNINGS AND PRECAUTIONSSystemic Atheroemboli and Cholesterol Microembolisee WARNINGS AND PRECAUTIONSLimb IschemiaNecrosisand Gangrene in Patients with HIT and HITTSsee WARNINGS AND PRECAUTIONSOther Clinical Settings with Increased Riskssee WARNINGS AND PRECAUTIONS

After reconstitutionCOUMADIN for injection is stable for 4 hours at room temperatureIt does not contain any antimicrobial preservative andthuscare must be taken to assure the sterility of the prepared solutionThe vial is for single use onlydiscard any unused solution.

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